Original Research 


Immunohistochemical over-expression of p53 gene in Oral Squamous Cell Carcinoma.

Dr. Sonal Mayur Chitroda , Dr. Menka Shah.

Abstract
Background: Mutation of the p53 gene is one of the most common events in oral carcinogenesis. Immunohistochemical over expression of p53 gene is considered as a marker of poor prognosis in many human cancers. Aims & objective: The present study aimed to evaluate a role of p53 overexpression in the prognosis of oral squamous cell carcinoma. Methods: It is a prospective cross sectional study that included total 30 oral biopsy samples diagnosed for oral squamous cell carcinoma and processed to analyse p53 over expression by immunohistochemical staining. Results: Out of 30 cases of oral squamous cell carcinoma, 17 cases (56.66%) were found positive for p53 over expression whereas 13 cases (43.33%) found negative. 22 cases (73.33%) were from well differentiated squamous cell carcinoma whereas 08 cases (26.67%) were from moderately differentiated squamous cell carcinoma. On the basis of intensity of p53 overexpression; 13 cases (43.33%) revealed strong nuclear positivity, 03 cases (10.01%) revealed weak nuclear positivity and 01 case (03.33%) showed moderate nuclear positivity. Out of 22 cases of well differentiated carcinoma, 10 cases showed positive overexpression of p53 whereas 12 cases were negative for overexpression. Out of 8 cases of moderately differentiated carcinoma, 7 cases were positive for p53 overexpression whereas 1 case revealed negative p53 overexpression. Hence, the results showed significant association of oral squamous cell carcinoma with the intensity of p53 expressions.(p value 0.0398) Conclusion: The p53 over expression is useful prognostic biomarker in oral squamous cell carcinoma and therefore more large scale studies are needed to evaluate its prognostic significance in the loco-regional population.

Key words: P53 over expression, Immunohistochemistry, Oral Squamous cell Carcinoma


 
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Pubmed Style

DSMC, Shah DM, . Immunohistochemical over-expression of p53 gene in Oral Squamous Cell Carcinoma.. JHSPE. 2022; 2(1): 1-5. doi:10.5455/jhspe.20220215110224


Web Style

DSMC, Shah DM, . Immunohistochemical over-expression of p53 gene in Oral Squamous Cell Carcinoma.. https://www.jhspe.in/?mno=56940 [Access: December 05, 2023]. doi:10.5455/jhspe.20220215110224


AMA (American Medical Association) Style

DSMC, Shah DM, . Immunohistochemical over-expression of p53 gene in Oral Squamous Cell Carcinoma.. JHSPE. 2022; 2(1): 1-5. doi:10.5455/jhspe.20220215110224



Vancouver/ICMJE Style

DSMC, Shah DM, . Immunohistochemical over-expression of p53 gene in Oral Squamous Cell Carcinoma.. JHSPE. (2022), [cited December 05, 2023]; 2(1): 1-5. doi:10.5455/jhspe.20220215110224



Harvard Style

, D. S. M. C., Shah, D. M. & (2022) Immunohistochemical over-expression of p53 gene in Oral Squamous Cell Carcinoma.. JHSPE, 2 (1), 1-5. doi:10.5455/jhspe.20220215110224



Turabian Style

, Dr. Sonal Mayur Chitroda, Dr. Menka Shah, and . 2022. Immunohistochemical over-expression of p53 gene in Oral Squamous Cell Carcinoma.. Journal of Health Sciences and Professions Education, 2 (1), 1-5. doi:10.5455/jhspe.20220215110224



Chicago Style

, Dr. Sonal Mayur Chitroda, Dr. Menka Shah, and . "Immunohistochemical over-expression of p53 gene in Oral Squamous Cell Carcinoma.." Journal of Health Sciences and Professions Education 2 (2022), 1-5. doi:10.5455/jhspe.20220215110224



MLA (The Modern Language Association) Style

, Dr. Sonal Mayur Chitroda, Dr. Menka Shah, and . "Immunohistochemical over-expression of p53 gene in Oral Squamous Cell Carcinoma.." Journal of Health Sciences and Professions Education 2.1 (2022), 1-5. Print. doi:10.5455/jhspe.20220215110224



APA (American Psychological Association) Style

, D. S. M. C., Shah, D. M. & (2022) Immunohistochemical over-expression of p53 gene in Oral Squamous Cell Carcinoma.. Journal of Health Sciences and Professions Education, 2 (1), 1-5. doi:10.5455/jhspe.20220215110224